Front Cover: Dioxygen Binding Is Controlled by the Protein Environment in Non‐heme Fe^II and 2‐Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene‐Forming Enzyme (Chem. Eur. J. 24/2023)

The cover shows the oxygen diffusion channel in class 7 histone demethylase (PHF8) and ethylene-forming enzyme (EFE). PHF8 catalyzes hydroxylation of its H3 K9me2 substrate, EFE two competing reactions ethylene generation substrate l-Arg hydroxylation. Although both enzymes initially have an off-line 2-oxoglutarate (2OG) conformation, upon binding, forms in-line superoxo complex, whereas uses complex. More information can be found Research Article by C. Z. Christov co-workers. (DOI: 10.1002/chem.202300138).